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Search Results for " Dipeptidyl Peptidase "

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天然化合物

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カタログ番号	製品名	別名	ターゲット
T15079	DBPR108		Proteasome , DPP-4
	DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.		Proteasome , DPP-4
T7369	Gemigliptin	LC15-0444	Proteasome , DPP-4
	Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)		Proteasome , DPP-4
T1502	Vildagliptin	NVP-LAF 237,LAF237	Apoptosis , Ferroptosis , Proteasome , DPP-4
	Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolit...		Apoptosis , Ferroptosis , Proteasome , DPP-4
T7369L	Gemigliptin Tartrate(911637-19-9 free base)	LC15-0444 tartrate	Proteasome , DPP-4
	Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibit...		Proteasome , DPP-4
T0191	Linagliptin	BI 1356	Ferroptosis , Proteasome , DPP-4 , Autophagy
	Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.		Ferroptosis , Proteasome , DPP-4 , Autophagy
T4042	Talabostat mesylate	Val-boroPro,PT100	Proteasome , DPP-4
	Talabostat mesylate (PT100) is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation protein. This agent may also stimulate the producti...		Proteasome , DPP-4
TQ0038	Brensocatib	AZD7986,INS 1007	Proteasome
	Brensocatib (AZD7986) is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively).		Proteasome
T0242	Sitagliptin	MK0431	Proteasome , DPP-4 , Autophagy
	Sitagliptin (MK0431), a new oral hypoglycemic (anti-diabetic drug), is a new dipeptidyl peptidase-4 (DPP-4) inhibitor. This enzyme-inhibiting drug is used either alone or in combination with metformin or thiazolidinedion...		Proteasome , DPP-4 , Autophagy
T16684	Puromycin aminonucleoside	NSC 3056	Apoptosis , Proteasome , Aminopeptidase , Antibacterial , Antibiotic
	Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
T6237	Trelagliptin	SYR-472	Proteasome , DPP-4
	Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.		Proteasome , DPP-4
T11526	DPP-IV-IN-2	H-Lys(4-nitro-Z)-pyrrolidide	DPP-4
	DPP-IV-IN-2 (H-Lys(4-nitro-Z)-pyrrolidide) is an inhibitor of both DP8/9 and dipeptidyl peptidase IV (IC50s: 0.1 and 0.95 μM).		DPP-4
T12710	Retagliptin Phosphate	SP 2086	Proteasome , DPP-4
	Retagliptin Phosphate (SP 2086) is pharmaceutical composition of DPP-4 inhibitor, for treating type-2 diabetes.		Proteasome , DPP-4
T6192	Alogliptin	SYR-322	Ferroptosis , Proteasome , DPP-4
	Alogliptin (SYR-322)(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9.		Ferroptosis , Proteasome , DPP-4
T1674	Nateglinide	A4166,Senaglinide	Potassium Channel , Proteasome , PPAR
	Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare ins...		Potassium Channel , Proteasome , PPAR
T2316	Omarigliptin	MK-3102	Proteasome , DPP-4
	Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency.		Proteasome , DPP-4
T4467	UAMC00039 dihydrochloride	UAMC 00039 dihydrochloride	Proteasome
	UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM.		Proteasome
T25340	Diprotin A	Ile-Pro-Ile	DPP-4
	Diprotin A (Ile-Pro-Ile) (Ile-Pro-Ile) is a dipeptidyl peptidase IV (DPP-IV) inhibitor.		DPP-4
T6999	Teneligliptin hydrobromide	Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)	Others , Proteasome , DPP-4
	Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 ...		Others , Proteasome , DPP-4
T7133	Anagliptin	SK-0403	Proteasome , DPP-4
	Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.		Proteasome , DPP-4
T8550	NDMC101		Others , NF-κB , Proteasome
	NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.		Others , NF-κB , Proteasome
T2401	Alogliptin Benzoate	SYR 322,Alogliptin(SYR-322)benzoate	Ferroptosis , Proteasome , DPP-4
	Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may inhibit inflammatory responses by preventing the...		Ferroptosis , Proteasome , DPP-4
T23358	Sitagliptin phosphate	Januvia,MK-0431 phosphate,Sitagliptin (phosphate)	DPP-4 , Autophagy
	Sitagliptin phosphate (MK-0431 phosphate) is a dipeptidyl peptidase-4 (DPP4) inhibitor.		DPP-4 , Autophagy
T6203	Saxagliptin	BMS-477118,Onglyza	Proteasome , DPP-4
	Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.		Proteasome , DPP-4
T2296	Trelagliptin succinate	SYR-472 succinate,SYR472	Proteasome , DPP-4
	Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2D).		Proteasome , DPP-4
T0178	Saxagliptin hydrate	Onglyza hydrate,BMS-477118 hydrate	Proteasome , DPP-4
	Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).		Proteasome , DPP-4
T0242L	Sitagliptin phosphate monohydrate	MK-0431,MK-0431 phosphate monohydrate	Proteasome , DPP-4 , Autophagy
			Proteasome , DPP-4 , Autophagy
T36583	Gly-Pro-pNA hydrochloride	Gly-Pro p-nitroanilide hydrochloride	Proteasome
	Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase IV and dipeptidyl peptidase IX.		Proteasome
T78410	Gly-Pro-AMC hydrobromide	Gly-Pro-AMC HCl
	Gly-Pro-AMC hydrobromide (Gly-Pro-AMC HCl) is a specific fluorescent dye used in cytofluorescence assays to detect Dipeptidyl peptidase IV (DPP-IV) activity.
T67852	Linagliptin Methyldimer		Proteasome
	Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.		Proteasome
T29019	TS-021	TS021,TS 021,TS-021 Free	DPP-4
	TS-021 is a selective dipeptidyl peptidase 4 (DPP-4) inhibitor with antidiabetic activity for the study of type 2 diabetes.		DPP-4
T78223	γ-Glu-Tyr	gamma-Glutamyltyrosine,gamma-GLU-TYR
	γ-Glu-Tyr (gamma-Glutamyltyrosine) is a kokumi peptide with competitive inhibition of dipeptidyl peptidase-IV (DPP-IV) and is used in the study of diabetes mellitus.
T68053	Denagliptin	GW823093	DPP-4
	Denagliptin is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor for the treatment of endocrine Ü metabolic diseases and can be used in the study of type 2 diabetes.		DPP-4
T21979	P32/98 (hemifumarate)
	P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a K i value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model. P32...
T27353	Fotagliptin
	Fotagliptin is a dipeptidyl peptidase IV inhibitor.
T25341	Diprotin B
	Diprotin B is a dipeptidyl peptidase IV inhibitor.
T22886	K 579		Others
	K 579 is a dipeptidyl peptidase IV inhibitor.		Others
T11049	Diprotin A TFA	Ile-Pro-Pro (TFA)	Others
	Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).		Others
T31378	Denagliptin tosylate	GSK-823093,GSK 823093,GW-823093,GW 823093,GSK823093,GW823093
	Denagliptin (GW823093 or GSK-823093) is a dipeptidyl peptidase IV (DPP-IV) inhibitor.
T25382	Epostatin
	Epostatin is a new dipeptidyl peptidase II (DPP-II, EC 3.4.14.2) inhibitor.
T26850	BMS-538305 HCl	BMS-538305,BMS538305,BMS 538305,BMS-538305 hydrochloride
	BMS-538305 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP-IV).
T70254	FE-999011
	FE-999011 is a dipeptidyl peptidase IV inhibitor.
T30166	ASP-4000 HCl	ASP4000 HCl,ASP 4000 HCl,UNII-7393JFE67B
	ASP-4000 HCl is an inhibitor of dipeptidyl peptidase 4 (DPP) with anti-hyperglycemic activity.
T27598	Imigliptin Dihydrochloride	Imigliptin
	Imigliptin Dihydrochloride, a selective dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type II diabetes.
T10082	DPP-IV-IN-1		Others
	DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM).		Others
T11450	Gosogliptin	PF-00734200,PF-734200	Others
			Others
T23705	Allo-Ile-isoindoline HCl	TC-E 5007,allo Ile isoindoline HCl,TC-E-5007,TCE5007,TCE 5007
	Allo-Ile-isoindoline HCl is an irreversible and selective inhibitor of dipeptidyl peptidase 8 and 9.
T26941	Camegliptin	RO-4876904-001,R1579,RG1579,RO-4876904,R-1579,RG-1579
	Cameglipti, a dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type 2 diabetes.
T68561	ASP-4000 free base
	ASP-4000 free base is a dipeptidyl peptidase 4 (DPP) inhibitor with antihyperglycemic activity.
T71117	AZD5248
	AZD-5248 is a potent, selective, first generation, oral inhibitor of dipeptidyl peptidase 1 (DPP1).
T13826	Prodipine hydrochloride		Others
	Prodipine hydrochloride for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit (IC50 of 4.5 μM and 30 μM, respectively).		Others

Compounds

DBPR108

T15079

Synonym:

Target: Proteasome, DPP-4

Gemigliptin

T7369

Synonym: LC15-0444

Target: Proteasome, DPP-4

Vildagliptin

T1502

Synonym: NVP-LAF 237,LAF237

Target: Apoptosis, Ferroptosis, Proteasome, DPP-4

Gemigliptin Tartrate(911637-19-9 free base)

T7369L

Synonym: LC15-0444 tartrate

Target: Proteasome, DPP-4

Linagliptin

T0191

Synonym: BI 1356

Target: Ferroptosis, Proteasome, DPP-4, Autophagy

Talabostat mesylate

T4042

Synonym: Val-boroPro,PT100

Target: Proteasome, DPP-4

Brensocatib

TQ0038

Synonym: AZD7986,INS 1007

Target: Proteasome, DPP-4, Autophagy

Puromycin aminonucleoside

T16684

Synonym: NSC 3056

Target: Apoptosis, Proteasome, Aminopeptidase, Antibacterial, Antibiotic

Trelagliptin

T6237

Synonym: SYR-472

Target: Proteasome, DPP-4

DPP-IV-IN-2

T11526

Synonym: H-Lys(4-nitro-Z)-pyrrolidide

Target: DPP-4

Retagliptin Phosphate

T12710

Synonym: SP 2086

Target: Proteasome, DPP-4

Alogliptin

T6192

Synonym: SYR-322

Target: Ferroptosis, Proteasome, DPP-4

Nateglinide

T1674

Synonym: A4166,Senaglinide

Target: Potassium Channel, Proteasome, PPAR

Omarigliptin

T2316

Synonym: MK-3102

Target: Proteasome, DPP-4

UAMC00039 dihydrochloride

T4467

Synonym: UAMC 00039 dihydrochloride

Teneligliptin hydrobromide

T6999

Synonym: Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)

Target: Others, Proteasome, DPP-4

Anagliptin

T7133

Synonym: SK-0403

Target: Proteasome, DPP-4

NDMC101

T8550

Synonym:

Target: Others, NF-κB, Proteasome

Alogliptin Benzoate

T2401

Synonym: SYR 322,Alogliptin(SYR-322)benzoate

Target: Ferroptosis, Proteasome, DPP-4

Sitagliptin phosphate

T23358

Synonym: Januvia,MK-0431 phosphate,Sitagliptin (phosphate)

Target: DPP-4, Autophagy

Saxagliptin

T6203

Synonym: BMS-477118,Onglyza

Target: Proteasome, DPP-4

Trelagliptin succinate

T2296

Synonym: SYR-472 succinate,SYR472

Target: Proteasome, DPP-4

Saxagliptin hydrate

T0178

Synonym: Onglyza hydrate,BMS-477118 hydrate

Target: Proteasome, DPP-4

Sitagliptin phosphate monohydrate

T0242L

Synonym: MK-0431,MK-0431 phosphate monohydrate

Target: Proteasome, DPP-4, Autophagy

Gly-Pro-pNA hydrochloride

T36583

Synonym: Gly-Pro p-nitroanilide hydrochloride

Target: Proteasome

Gly-Pro-AMC hydrobromide

T78410

Synonym: Gly-Pro-AMC HCl

Target:

Linagliptin Methyldimer

Synonym: TS021,TS 021,TS-021 Free

Target: DPP-4

γ-Glu-Tyr

T78223

Synonym: gamma-Glutamyltyrosine,gamma-GLU-TYR

P32/98 (hemifumarate)

Synonym: Ile-Pro-Pro (TFA)

Target: Others

Denagliptin tosylate

T31378

Synonym: GSK-823093,GSK 823093,GW-823093,GW 823093,GSK823093,GW823093

Synonym: BMS-538305,BMS538305,BMS 538305,BMS-538305 hydrochloride

Synonym: ASP4000 HCl,ASP 4000 HCl,UNII-7393JFE67B

Target:

Imigliptin Dihydrochloride

Synonym: PF-00734200,PF-734200

Target: Others

allo-Ile-isoindoline HCl

T23705

Synonym: TC-E 5007,allo Ile isoindoline HCl,TC-E-5007,TCE5007,TCE 5007

Target:

Camegliptin

T26941

Synonym: RO-4876904-001,R1579,RG1579,RO-4876904,R-1579,RG-1579

Prodipine hydrochloride

T13826

Synonym:

Target: Others

カタログ番号	製品名	ターゲット
T16838	Saikogenin A	Proteasome , DPP-4
	Saikogenin A is a dipeptidyl peptidase-4 inhibitor.	Proteasome , DPP-4
TN1418	Azaleatin	DPP-4
	Azaleatin is a natural product from Rhododendron simsii. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for type-2 diabetes and obesity studies.	DPP-4
T75493	Ellipyrone B
	Ellipyrone B, a γ-pyrone-based macrocyclic polyketide with antihyperglycemic properties, demonstrates inhibitory activity against dipeptidyl peptidase-4 (IC 50 =0.48 mM) [1].
T39219	Ficusonolide
	Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.
T75492	Ellipyrone A
	Ellipyrone A, a γ-pyrone-based macrocyclic polyketide, demonstrates inhibitory activity against dipeptidyl peptidase-4 (IC 50 = 0.35 mM). Additionally, this compound exhibits anti-glycolytic effects on α-glucosidase (IC ...
T83863	Fluostatin A sodium
	Fluostatin A, a fluorenone compound initially isolated from Streptomyces, demonstrates selective inhibition towards dipeptidyl peptidase 3 (DPP-3) compared to DPP-1, DPP-2, and DPP-4 with IC50 values of 0.44 µg/ml for DP...
T81898	Lyciumamide A
	DPP-IV-IN-5, derived from Lycium barbarum fruits, demonstrates moderate agonistic activity towards peroxisome proliferator-activated receptor (PPARγ), showing EC50 values between 10.09 and 44.26 μM, and exhibits inhibito...

天然物製品

Saikogenin A

T16838

Synonym:

Target: Proteasome, DPP-4

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-01358	DPP3 Protein, Human, Recombinant (His)	Human	E. coli
	Dipeptidyl peptidase 3(DPP3), is a member of the S9B family in clan SC of the serine proteases. DPP3 has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. This c...
TMPH-02628	Cathepsin C Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function.
TMPH-03279	DPP4/CD26 Protein, Rat, Recombinant (His & SUMO)	Rat	E. coli
	Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, ...
TMPH-00067	Venom dipeptidyl peptidase 4 Protein, Apis mellifera, Recombinant (His & Myc)	Apis mellifera	E. coli
	Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. May process promelittin into its active form ...
TMPY-02737	DPP2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	DPP2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.7 kDa and the accession number is Q9ET221.
TMPY-00777	DPP2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	DPP2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.6 kDa and the accession number is Q9UHL4.
TMPY-01854	DPP10 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein w...
TMPK-00377	DPPIV/CD26 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)	Cynomolgus,Rhesus	HEK293 Cells
	CD26/dipeptidyl peptidase (DPP)IV is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metast...
TMPY-00732	Cathepsin C Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also kno...
TMPY-02070	Cystatin SN Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cystatin-SN, also known as Cystain-SA-I, Cystatin-1, Salivary cystatin-SA-1 and CST1, is a secreted protein which belongs to thecystatin family. The cystatin superfamily encompasses proteins that contain multiple cyst...
TMPY-06885	SARS-CoV-2 XBB.1.16 (Omicron) Spike S1+S2 trimer Protein (ECD, His)
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-01027	Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. I...